| Organ Transplant AU & NZ | |
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| Tweet Topic Started: Dec 4 2011, 08:54 AM (151 Views) | |
| JOCHAN | Dec 4 2011, 08:54 AM Post #1 |
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Hi teamates, not been able to research much about the logistics but found quite a bit on organs transplantation...see if this would help. |
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| waiyan | Dec 4 2011, 03:34 PM Post #2 |
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Hi All, Manage to find some info about organ storage condition... but dont really understand Pls take a look and we can discuss further. http://www.ncbi.nlm.nih.gov/pubmed/10459537 Improved preservation solutions for organ storage: a dynamic study of hepatic metabolism.Changani KK, Fuller BJ, Bell JD, Taylor-Robinson SD, Moore DP, Davidson BR. SourceDepartment of Surgery, Royal Free Hospital and Medical School, London, United Kingdom. kchangan@rpms.ac.uk AbstractBACKGROUND: Organ cold storage times may be extended by modifications to organ preservation solutions. METHODS: Three preservation solutions were investigated for their ability to maintain viable hepatic bioenergetics in stored pig livers: modified University of Wisconsin (mUW); mUW+adenosine (1.34 g/L), and mUW+ iloprost (10(-8)mol/L), a prostacyclin analogue. Using human liver retrieval and storage techniques, pig livers were stored on ice for either 2 or 16 hr, after which phosphorus-31 spectra were collected every 2 min during the period of cold ischemia and hypothermic reperfusion (HtR). During HtR, metabolite concentration changes associated with phosphomonoesters, inorganic phosphate, gamma-nucleotide triphosphate (NTP), and beta-NTP were measured for all solutions. RESULTS: After a 2-hr storage, beta-NTP regeneration in mUW+iloprost produced +57.7% (P<0.01) more beta-NTP, at a faster initial rate of +66.3% (P<0.001), compared with mUW, and mUW+adenosine regenerated +35.6% (P<0.05) more beta-NTP, compared with mUW. Storage for 16 hr did not slow the rates of regeneration, and the total NTP produced during the course of the experiment remained unchanged for the respective preservation solutions. Cessation of HtR invoked a net accumulation of nucleotide diphosphate, indicating differential kinetics of adenine nucleotide hydrolysis. CONCLUSION: This large animal model study suggests significant improvements to human organ preservation solutions using prostacyclin analogues and adenosine with respect to hepatic bioenergetics. |
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| waiyan | Dec 4 2011, 03:40 PM Post #3 |
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Hi.... more.. this is interesting.. http://www.dailymail.co.uk/health/article-1103833/Donor-organ-storage-machine-keeps-kidneys-fresher-boosts-transplant-success.html Donor organ storage machine keeps kidneys fresher, boosts transplant success A special storage machine keeps donor kidneys fresher for transplantation than ice, a study has shown. Kidneys stored in the LifePort Kidney Transporter were almost half as likely to fail in the year after transplantation than those packed in ice, the team says. And transplant patients given machine-transported kidneys were 43 per cent less likely to suffer a delay before their new organ started working. The traditional method of preserving transplant kidneys removed from dead donors is 'static cold storage' - where the organ is chilled with a preservative solution and placed in an ice box. Using the LifePort Kidney Transporter, a different method known as 'hypothermic machine perfusion' is employed. Instead of being packed in ice, the organ has preservative solution continuously pumped through it at temperatures of between 1C and 10C. Interest in machine-storage of kidneys has grown as a result of a general deterioration of organ quality, which has increased the failure rate of transplants. |
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| robert_marshall | Dec 5 2011, 04:51 AM Post #4 |
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I found a company called Transmedics that has a machine to keep organs oxygenated and therefore alive for longer. http://www.transmedics.com |
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| robert_marshall | Dec 5 2011, 04:59 AM Post #5 |
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I also found a company that is doing Organ Transport in America. http://quick.aero/quickintl/life-sciences/medical-courier-services/ |
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| JOCHAN | Dec 5 2011, 03:59 PM Post #6 |
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Hi, i found this web also very interesting, it covers from policies, law to standardization packaging, labeling & transporting of organs etc etc http://optn.transplant.hrsa.gov/PoliciesandBylaws2/policies/pdfs/policy_2.pdf |
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| jinsun | Dec 8 2011, 08:16 AM Post #7 |
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http://www.transplant-observatory.org/Data%20Reports/2010%20Report%20final.pdf pls check page 14 (NZ -2010 Data) Observatory on Donation and Transplantation |
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