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| Nystatin and reason why some cannot tolerate it | |
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| Tweet Topic Started: Aug 28 2007, 04:29 PM (91 Views) | |
| ML | Aug 28 2007, 04:29 PM Post #1 |
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Master's Degree
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I wanted to post this information on Nystatin. It came from the purplepuzzleplace blog, a woman with a baby who has severe allergies to corn and numerous other foods, plus candida. It may explain why some people cannot seem to tolerate Nystatin at all and others are not affected. "By the way, nystatin is an antifungal organic compound. It is derived from the bacteria Streptomyces noursei, which was originally discovered in dirt by two women who were trying to find an antifungal antibiotic. S. noursei is often cultured in mediums made up of various ingredients, including soy broth, yeast extract, and glucose (glucose is generally corn-derived). This paper says, "For nystatin production, S. noursei strains were grown for 120 h in 50 ml SAO-23 medium (g per l: glucose, 45; NH4NO3, 2·5; corn meal, 3; MgSO4 . 7H2O, 0·4; KH2PO4, 0·2; CaCO3, 5) in shake flasks at 28 °C (220 r.p.m.). Cells were then pelleted and extracted with DMSO, and extracts analysed by HPLC." It seems the cornmeal culture is a standard method for producing nystatin." |
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6:39 PM Jul 10