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In animals, the acute toxic effects are diarrhea, gastrointestinal lesions, focal cardiac necrosis, hepatic necrosis, renal tubular necrosis, testicular atrophy, respiratory difficulties, and depression of the central nervous system. Symptoms should be treated with supportive therapy.. Clinical signs that may indicate an overdose are sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia.MisoprostolMifepristone can cause side effects such as headache, nausea, vomiting, diarrhea, bleeding, and heavy cramping.. Order Misoprostol online. . This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are using MisoprostolMifepristone.For patients who experience intolerance, diclofenac 75 mg/misoprostol 200 mg orally 2 times daily or diclofenac 50 mg/misoprostol 200 mg orally 2 times daily can be used, but are less effective in preventing ulcers. Cumulative total daily doses of 1600 mcg have been tolerated, with only symptoms of gastrointestinal discomfort being reported. The toxic dose of misoprostol in humans has not been determined
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