Welcome Guest [Log In] [Register]

Image and video hosting by TinyPic







Image and video hosting by TinyPic


Image and video hosting by TinyPic
Image and video hosting by TinyPic




[The Last Pures IRC Channel]
#TLP

[The Last Pures - Quick Links]
[The Last Pures - Rules]
[The Last Pures - Introduction]
[The Last Pures - Junior Application]
[The Last Pures - Member Application]

[Public Clan Chat]
TLP CC

[Community]
Runescape Community
Pure Warfare


Add Reply
Scientists Reverse the Effect of Aging in Mice
Topic Started: Dec 29 2010, 04:41:30 PM (98 Views)
Null
Member Avatar
You're a Queer!

http://www.ctv.ca/CTVNews/Health/20101129/reversing-aging-mice-101129
 
Scientists in Boston have made an astounding discovery, taking aging mice and turning them young again, like tiny little Benjamin Buttons.

Just like the title character in the Hollywood film version of "The Curious Case of Benjamin Button," the mice appeared to not only stop aging but grow younger.

Molecular biologist Dr. Ronald DePinho at Harvard Medical School in Boston was able to pull off the feat by playing with "telomeres" -- the protective DNA caps on the ends of our chromosomes.

The caps, which have long been implicated in aging, prevent our chromosomes from "fraying" and the genes inside them from "unravelling."

Scientists have long known that a little bit of our telomeres erodes each time our cells divide. Previous research has shown that people with longer telomeres tend to live longer, whereas those with shorter telomeres suffer more from age-related diseases, such as Alzheimer's.

A few years ago, DePinho and his research team devised a way to engineer mice so that they lacked a working copy of the gene that regulates the production of telomerase, which is an enzyme that strengthens telomeres and whose production declines over time.

Instead of dying at three years old, the genetically engineered mice died at about six months. By the time they died, they had become infertile, their coat hair had turned grey and they had developed age-related conditions such as osteoporosis.

DePinho wondered whether he could reverse the aging in the mice if they suddenly began making telomerase again.

So he took a group of engineered mice and added back the telomerase gene, but left it inactive. His team then allowed the mice to age for six months, until they were the equivalent of 80-year-old humans. They then gave the mice a drug that "switched on" the telomerase gene.

One month later, not only did the new production of telomerase stop the aging process in the mice, it appeared to actually undo the premature aging so that the mice became the physiological equivalent of young adults.

Even DePinho was surprised at how effective the experiment was.

"We expected to see a slowing or a stabilization of aging. Instead, what we found was a dramatic reversal in aging," he told CTV.

"The shrunken brains increased, new neurons were formed, the coat hair was restored to a new sheen."

DePinho notes that the treated mice went on to have a normal lifespan. They were simply healthier and biologically younger.

DePinto and his colleagues stress that the study was a "proof-of-concept" experiment, designed to show that changes to telomerase can affect aging. There are still many questions to answer before an experiment can be tried on humans.

For example, some research has shown that telomerase seems to help cancer tumours grow faster. DePinho says his team didn't observe any cancers in the mice, but then the telomerase was activated for only one month.

"This teaches us something fundamental about aging: that aged tissue -- even very aged tissue -- retains the ability to rejuvenate itself," he said.

DePinho says it's possible the method could be used to treat people with rare genetic premature aging syndromes. Whether the technique could help reverse normal aging still remains to be seen. Still, he says the findings were worth sharing and appear in the journal Nature.

"The results were so dramatic that we wanted to get them out to the research community as soon as possible so we could inspire the research community to move forward on these findings," DePinho said.


interesting
Posted Image
Offline Profile Quote Post Goto Top
 
Xbl Chris
Member Avatar


tl;dr obviously rofl
16 year old prodigy


Offline Profile Quote Post Goto Top
 
+Nessi|Crims0n™
Member Avatar
God

Shit man, thats cool, insane that stuff like this is actually possible, cant imagine what could happen in future.
Posted Image
R.I.P Sophie, forever and always <3
Truth is, everybody is going to hurt you; you just gotta find the ones worth suffering for." -Bob Marley
Offline Profile Quote Post Goto Top
 
Null
Member Avatar
You're a Queer!

Xbl Nick's Little Brother
Dec 29 2010, 04:51:36 PM
tl;dr obviously rofl
it's ok lolz, not everyone is smart enough to read it :D
Posted Image
Offline Profile Quote Post Goto Top
 
`Hunter
Member Avatar
Reppin TLP since the beginning xD

Makes sense
Hunter + Adam = Wendys Unit <3

Posted Image
Offline Profile Quote Post Goto Top
 
Rangrgoto1
Member Avatar


That's awesome.

I kind of suspected that scientist would discover this sooner or later. I'm not so sure if its a good idea to release it to the public, if they find a way to do it without increasing the chance of getting tumors. The Earth is already over populated, releasing this drug, or surgery, or what ever it may be, to the public may just make the earth even more populated. Of course, I could be wrong.
Accepted as a Junior 11-22-09
Accepted as a Member 2-7-10
Accepted as a Proud Member 6-24-10
Promoted to Experienced Member 9-10-10
Promoted to Elite Member 11-13-10
Promoted to App Manager 5-1-11
Demoted to Elite Member 6-24-11

[img]http://imgur.com/yNKwA.png[/img]

Proud Leader of #Team-Critical

Proud Co-founder of #Trippin

[img]http://i.imgur.com/JAunb.png[/img]
Offline Profile Quote Post Goto Top
 
Karl
Member Avatar
Ever

yeah its not gonna be a good idea to use this on humans, will have catostrophic effects, imagine a world where nobody dies from old age? also pedophiles will have a field day being young again :/
[img]http://i151.photobucket.com/albums/s125/imnotwaste/leoriginalederple_13fafd_2419714.gif[/img]
Offline Profile Quote Post Goto Top
 
Adam
Member Avatar
Lord of the Turmoilers

Impressive

#randy
Posted Image
Posted Image
Ex Tlp Events Team
False tears brings pain to those around you, but a false smile brings pain to one self.
Is God willing to prevent evil, but not able? Then he is not omnipotent. Is he able, but not willing? Then he is malevolent. Is he both able and willing? Then whence cometh evil? Is he neither able nor willing? Then why call him God?
— Epicurus



Offline Profile Quote Post Goto Top
 
Sir Janis
no im not

There was this anti aging shit prediction in that baba vada yadayada topic.
Posted Image
Ty Null <3. Much love.
Offline Profile Quote Post Goto Top
 
_Kitsym_
Member Avatar


You people are so retarded sometimes.

They made the rats' telomere inactive, then made it active again.

They're not getting younger, their body is just recovering. They're not going to live any longer. Only way this is (currently) beneficial is for people with whatever that illness is that makes people age faster.
I'm not gay, I just want to boogy to some Marvin.
Guest - Member - Proud - Elite - Proud - Experienced - Member - Proud - Elite - Events - Honorable - Guest - Ex-TLP - Special Guest - Honorable - Banned - Guest - Member - Proud - Experienced - Honorable - Guest - Honorable - Guest - Honorable - Elder

Posted Image
(00:23:12) <+Tofu_Pirate> Always imagined Kitsym as a turtle

Offline Profile Quote Post Goto Top
 
Big Alex 67
Eleven Defense Lord

interesting indeed

Attack Big Alex 67 (Level-85+10) / 2 more options

Posted Image
Offline Profile Quote Post Goto Top
 
Cl4ssic|Slay
Member Avatar


Karl
Dec 29 2010, 05:23:09 PM
yeah its not gonna be a good idea to use this on humans, will have catostrophic effects, imagine a world where nobody dies from old age? also pedophiles will have a field day being young again :/
they stilll died of old age, but had no symptoms of the old age
[img]http://i128.photobucket.com/albums/p187/i60106/f2ppkerm.png[/img]

Awards
Long sig is long



[img]http://images1.wikia.nocookie.net/__cb20100820173248/runescape/images/5/5b/Rigour.png[/img] [x] [img]http://images4.wikia.nocookie.net/__cb20100413125161/runescape/images/9/93/Augury.png[/img] [x] [img]http://images3.wikia.nocookie.net/__cb20101028210760/runescape/images/d/d0/Fire_cape.PNG[/img] [x] [img]http://images1.wikia.nocookie.net/__cb20091219014206/runescape/images/6/6b/Adamant_gloves.png[/img] [x] [img]http://images2.wikia.nocookie.net/__cb20100831102940/runescape/images/3/35/Overload_3.png[/img] [x][img]http://images1.wikia.nocookie.net/__cb20100421031721/runescape/images/c/cf/Arcane_Stream_Necklace.png[/img] [x] [img]http://images1.wikia.nocookie.net/__cb20100426045221/runescape/images/5/52/Chaotic_rapier.png[/img] [x] [img]http://images1.wikia.nocookie.net/__cb20101008043933/runescape/images/a/af/Zamorak_halo.png[/img] [ ] [img]http://images3.wikia.nocookie.net/__cb20100223101358/runescape/images/1/1f/Onyx_ring_imbued.png[/img] [ ]
Offline Profile Quote Post Goto Top
 
1 user reading this topic (1 Guest and 0 Anonymous)
DealsFor.me - The best sales, coupons, and discounts for you
« Previous Topic · Old Debate · Next Topic »
Add Reply